I've beaten myself up so much giving her this drug, I felt I could trust the vet and the drug company but we obviously cant and it's all about making more money. His blood work came back normal but the vet called me to ask if his simparica somehow coincided with time of the seizures. We took him to vet and they gave nausea meds and kept him overnight. We just brought him home from hospital today. The third ingredient in Simparica Trio is pyrantel. Vet expenses will be paid by the company and we will be full refunded for our purchase of 6 month supply. Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . Its Sunday night and still vomiting. I made some chicken and rice. My dog is currently in an emergency hospital in Chicago with my daughter. Kristine, unfortunately my sweet Dolly passed away on October 9th. I gave this trash to my 5 month old JRT yesterday. Topical only for me from now on. This Tuesday the 17th I had given my dog simparica trio for 27lbs dose. Lethargic and confused. 5 hours after the dose she's home resting. You can do this by reporting to the drugs manufacturers, who are required to report this information to the FDA, or by submitting a report directly to the FDA. Doing better now, 2 days later. Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. FREE shipping and the BEST customer service! It still makes me sick to think about her last month we miss her so much. By Tuesday evening symptoms came back worse. It started working on him right away, Diarrhea. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. No simparica for them either! Im wondering if anyone else has seen these types of symptoms. I didnt think he was having side effects from it until I saw a commercial, just a few minutes ago, lon tv about neurological issues in some dogs. We are closely monitoring him. Called Vet tonight and got a first appointment for tomorrow morning . But now I'm almost convinced that they could have been seizures, and I just pray that they weren't, and pray that he doesn't have to experience anymore troubles. Let us now look at possible side effects when administering Simparica. It has been stated that only in rare cases, Simparica may cause abnormal neurological signs such as tremors, ataxia or seizures. We have an appt for a skin scraping. Just a little nervous !! We rescued another dog. Still waiting on the vet and waiting to talk to ASPCA poison control. Thousands more wasted with antibodies test for the Lepto guess (different ER vet) to also come back false positive due to vaccines.. my poor baby already had a rough life being abandoned. I did and they said they are going to report it to the FDA. Haven't noticed any other symptoms to him besides the puking, not eating and skittish. Side effects are uncommon, but may occur in some cases. Im done with this drug! Took to vet and she said it could be the Simparico Trio. I gave our boy, Yogi his first dose of Simparica TRIO on 11/17/2020. (Ours never did, she died 4 months later.) A week after I lost her I got COVID and was in the hospital for 20 days. Hope all is well .my dog is 3,ive had him on Simparica trio for about 1.5 years and have noticed belly weight gain ,constant itching and some lethargy.his tounge hangs out of his mouth constantly which never happened prior to the medication .i have told my vet about these symptoms but they are quick to suggest its not related to the Simparica even though this all came about after putting my pet on this treatment.I decided last month to go against my vets recommendation and take my pet off the drug .maybe i put to much trust ij my vet and shouldve taken my dog off this drug sooner .better late then never .anyone suggest a tick and flea treatment less harmful for dogs ?? My dog has had 3 seizures in the past from wearing a flea collar. Please advise! Is there hope? Now her dog is very sick and she has to take the dog to the vet every day in the past week. Sarolaner is an acaricide (kills ticks and mites) and insecticide (kills fleas) belonging to the isoxazoline class of drugs. How is Simparica Trio Chewable Tablets for Dogs sold? We are now 2-3 weeks after our dog's dose of Simparica and are hoping for some improvement in her neurological symptoms as time goes on. She was terrified and we were too. Hi there, So sorry to hear about your dog. This drug has caused our dog to loose his footing and not eat. Will be back at PetSmart on Monday. I don't recommend anyone risk their pet's life just to be a little easier having a pill to take. We did a cortisone pack to help him manage his "arthritis" symptoms that I totally feel were related to the simparica. Simparica is good at killing contagious parasites that cause mange and scabies. I just wanted them gone and for him to feel better. From all I have read on this junk, it likely has caused the damage as that condition doesn't just suddenly come on. I have a chihuahua/miniature pincher mix dog thats 9 yrs. This happened to our 2yr old frenchie last Friday. I gave my morkie poo simparica trio from age 4 months until age 1 on advice of his vet. 2-6 days in vomiting here and there. The office girl not the vet said if it my dog threw up within one hour after eating her pill - then it is safe to give her another one. Zoetis claims it will be out of his system in two months and I should not see lasting effects, so I am hopeful but worried and telling everyone I know NOT to use this poison. All oral tick meds are a risk. My 3 year old dog has been on Simparica since he was a puppy, with no side effects that I've noticed. have been seen after using medications in this class of drugs. She has been itching uncontrollably since I gave her the simparica. We immediately gathered her up and took her to the vet. He had ONE dose that evening and completely lost his appetite within a couple days. It is a very traumatic experience that I saw my 1 year old dog go through and now no lo ever here. Hoping for a good outcome!!! She has NEVER done that before. He seemed to get a little better over the next week until he woke at 5am vomiting and having diarrhea and very lethargic. Moxidectin stops heartworm . In addition to the tremors, have you noticed any . Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching . Sometimes I think he is either blind or deaf. Its now about May 16th 2021. Related questions. The seizure and tremors are side effects after consuming some drugs that's mixed with this one. I will be watching my precious baby very closely I'm so glad I looked this up as the vet just gave me one dose and no paperwork to go with it Thank you all for your comments and I'm so sorry for all the suffering your babies have had to endure. He seemed okay with his next dose January 1, so we renewed the prescription, and I gave him the February dose too. She seems to be feeling better but still very concerned of why these levels are still up. My Labradoodle had extreme diarrhea last night. Didnt notice anything with first dose. I am very worried I called the vet they said oops sorry they made a mistake. If so how long did it take? Yep days ago started vomiting and having seizures. Im a new pet owner and this will sound ignorant Im sure but I had NO IDEA this is how flea meds works and completely trusted my vet who knows my dogs past sensitive history and I was given the drug not even in its package so I could read anything about it but in individual pills. I PRAY that our baby is okay with this second dose. No appetite, not like Charlie. I am terrified--wish I would of seen this sooner. She is more worried about excessive thirst, lip smacking and her kidneys. Plan to take him to see the vet tomorrow. I even said "I am reading a blog, right now, with pages of stories about this drug and the side effects". I'm besides myself. I feel so bad ,my 8weeks cockerspaniel hasnt been the same 24 hours of giving first dose of Simparica trio.My boy has been distressed with lethargic conditions,sleepy and peeing . Im now scared half to death. Pyrantel pamoate is a nematocide (kills some worms) belonging to the tetrahydropyrimidine class. Within a week one of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners. How do I get this out of his system and what are you using instead? Side-Effects Of Simparica Trio Tablets There are some mild side effects like Vomiting Diarrhea Loss of appetite Dog owners should be aware that these tablets are not suitable for all dogs. Another possibility would be that the dosage was to high for her (simparica comes in three different dosages). Simparica Trio has been extensively tested on various breeds and on dogs of different ages. He said it would take care of ticks and Trifexis doesn't. Today is day three and she is a little better, with fewer episodes of tremor and more often able to walk without falling. I have a vet appointment tomorrow to figure it out. Would appreciate any opinion you all may have. I gave my dog his first dose April 8th. We did not make the connection until today. I wish I would have seen this site before I gave it my Matty. This should be taken off the market-it's just a BIG pharmaceutical moneymaker at the expense of animals and their unsuspecting owners. We reported it with the company and they are reimbursing for vet bills, maybe you can report as well. Thankfully there have been no other side effects. The vet has reported it (at least she too thinks it came from the drug) and a chiropractor checked her for the possiblility of slipped disc etc and said it's not that. I have always used topical tx. I say yes! The American Heartworm Society recommends year-round heartworm prevention for all dogs in the United States, and the Companion Animal Parasite Council recommends broad-spectrum parasite control to prevent heartworms, intestinal parasites, fleas, and ticks for all dogs in North America. That is the only thing that has changed in her routine. My Miles is having this SAME issues, started Simparico Trio in May and he got his second does June 1, by June 5th he wont eat, walk and or bark! The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. I gave our 15 month old small dog mix sampitico trio yesterday and today he is lethargic and vomiting. Some dogs improve, some don't, not a clear answer why. How can you give a dog a pesticide to ingest. The most common Simparica Trio for dogs side effects are; Lethargy Vomiting Diarrhea Loss of appetite Polydipsia Polyuria Hyperactivity Hyperactivity, polydipsia, and polyuria happened in very rare cases. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. We live in Texas and I have only used an isoxazoline preventative when insect populations get out of control in my area, like they are now. He is just laying in his crate . . This was the 2nd does I have him. The only thought in my head was to get home and give it to my puppy who has had few fleas, but many itching problems. She would constantly twirl in left circles. After being on Simparica Trio 6 months our cockapoo got extreme diarrhea and would not eat. 100% effective, zero side effects. Im switching back to the protection he used before Simparica Trio. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewablefor protection against: . Sorry, cant see you for 4 days. He has been very healthy, and it does not seem to bother him, but it is becoming more noticeable recently. How old was your pup? My American Akita puppy took this pill on August 8th. She has been very unpredictable and snapping at people but this is improving. Hello to everyone and I am so sorry we had to meet under these circumstances. But today she isnt eating well, had a bout of diarrhoea and is very tired. My personal dog has had no issues at all, and she's been on it for nearly two years. That trip cost $400 and the result was he needed Simparica flea treatment. Zoetis (Simparica, Simparica Trio, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see How to Report Animal Drug and Device Side Effects and Product Problems. Is there any good outcomes from this tablet? He has been eating the same organic GF food for the past several years. At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. This drug needs to be pulled off the market! I'm so angry this medication is on the market. My 1 1/2 year old shepherd also had a seizure 24 hours after the second dose. (My first warning sign right there). Im convinced the medicine caused this and now she cant walk. I thought right away it must be the new meds! - she's had several episodes since then. It works by creating uncontrolled neuromuscular activity leading to death in fleas as well as some ticks and mites. I went home and somthing didn't feel right, but I read the leaflet and it said no known side effects. But unfortunately it's only a dog is the big Pharma tune. Sorry for the late replywe took our boy to the ER and after 2 days on fluids and a shot of Percorton, he was diagnosed with Addison's Disease. It is the flea and tick component that is the problem. I've read that simparica takes 35 days to get out of their system. old . Those jaw spasms have decreased but were pretty alarming in Dec and January. Fortunately, no seizures but dark yellow diarrhea and puppy has been drinking water like crazy and peeing even while asleep. He has been getting groomed since he was 3 months old but we've noticed that he has been getting more anxious with time. What are the side effects of Simparica Trio Chewable Tablets for Dogs? She won't drink E walk or anything The doctor seemed to push this drug on me because the kombi guard was on back order. I wish I could get this out of her system now. But few people read it or think it must be a million to one problem. The flavored, chewable tablets were consumed . She gets anxious and paces if I run into the grocery store even though my husband sits in the car with her. It went away, I thought the diarrhea was from some of the junk she eats off of the ground. Just gave this to my 2 year old 77 lb boxer 5 hours ago and I'm SCARED! She became extremely lethargic and feverish so we rushed her to Hospital. It is Now 3 pm and Lily is on her way to the animal hospital and most likely going to have to spend the night, we will flush her with iv and hope It helps Flush It out Of her system. She had been on the Seresto collar and Tri-Heart for 8 years with no issues. This morning I caught him chewing the end of his tail and eating his fur. This is so awful. You don't think I'm going to continue with this poison. He has horrible water like stools. She falls when she runs and when going up and down stairs. If my dog dies, which does not look too good right now for him, I will stop at nothing to make the company's life miserable. Keep the medication in the blister packs provided until ready to use in order to protect from moisture and light. Hopefully yours will be lucky and return to normal. They said , he has a Autoimmune Hemolytic anemia . This content shouldnt take the place of advice by your vet. I will use Sentinel and Pet Armor on her as this is what I have always gjven my dogs with no problems. Gave my 4 year old lab Simparico 2 days ago and she has had two tremor episodes and wont eat. Humans are another matter. Today is Friday. Our vet gave us this medication for our 8 week old Great Dane puppy. The diarrhea and vomiting went away after a few days but the cough has lingered for over a month now even with treatment. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a . Drinking water and peeing excessively. Also - do NOT use Bravecto for females you intend to breed. I came across this site and read so much about symptoms that I now realize he has been having. He took simparica trio 3 weeks ago and I cant wait until its out of his system! I gave my six-year-old dog SIM perica because the combo guard was on back order. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. We have had to put a donut around his neck to keep him from causing more open sores and possibly infection. Nothing stopped the seizures and our Pickles passed away after just a few months of symptoms. The ONLY thing that could cause such a huge change in behavior and personality had to be giving him the Simparico Trio the previous week. Buy Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 12 Chewable Tablets (12-mos. Thankfully I have had experience with dealing with this with my kids and relatives so I dosed him with Benadryl. I will have to keep an eye out on her. I hope these steps will prevent anyone else's pet having to endure this. If you think that your dog has had an overdose of Simparica, contact your vet immediately to seek treatment. The vet office called simparica hotline to find out if it was safe to give her another one. About 11 months ago our vet recommended Simparica Trio. She's not drinking water or eating all she wants to do is sleep. I was furious with the drug and the prescriber too. I called the vet and they said it was likely brought on by stress. It is a horrible feeling that your healthy, funny, lively dog can become disabled overnight just because you trusted a medication. Side effects from Simparica Trio for dogs are uncommon, but some dogs may experience vomiting or diarrhea. It went away. My other Lab after 5 days started having severe diaherria (black at first, now golden) and now throwing up too. His first was a week after taking his simparica. My 1.5 yr old German Shepherd was a happy, playful healthy dog until this Poison and now I blame myself for what she is going through. She was shaking like she was freezing. Please think these things through before subjecting your pet to internal insecticides. Bravecto has six topical solutions for dogs by weight/size. She has been taking the medicine since she was 6 months and she has gotten bigger so her dosage was increased. He is still not himself, walks very slowly and is definitely not feeling his best. The term off-label or extra-label use means that a medication is used in a way or in a particular species that is not specified on the medication label. Maybe? Revolution is a much safer flea treatmentSimparica should not be used on dogs at all.PERIOD !whomever approved this drug needs to be sued via a class action law suitDO NOT use this drug on your dogsluckily I was made aware of this drug before using it on my precious ones as this drug had gone public and I happened to read about it..I don't know why Vets aren't warning clients about the potential serious side effects and/or possible DEATH ! I give my dogs Simparica at the beginning of each month. She is healing and has no new rashes or sores. I too would like to know how long this symptom lasted in other dogs who experienced the same issue. One has done great only notice that he is drinking a lot of water. How can it not be the Simparica that did this to my baby when nothing else changed. Really angry this drug is on the market and pushed by many vets. Im wondering if there is any correlation as we havent changed anything else with him. all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. After 9 days he began vomitting, even water, and mouth chattering like he was scared. She is still eating but she is drinking more water. Other alternative drugs are likely to offer poorer protection. I thought maybe it was just a allergy break out which she's never had this long now I'm wondering if she's continuing to have a reaction. The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). Can someone please tell me if their dogs got better after taking the pill? Exactly. The next morning, she had uncontrollable tremors and could not walk without falling down. Thank you for this information. This is taken from the article printed above all these comments "Simparica works by impacting the nervous system of invertebrates such as fleas and ticks. I put water with electrolytes by his cage & food . I'm not going to make her a test case by giving her another dose next month. I realized it was from the simparica. Kind of ooze. I couldnt figure it out until I googled all the medications the vet has prescribed for her then I came across this forum and I am pissed!! my vet recommended this for both my yorkies. I would NEVER recommend this medication. First time for this adverse reaction. I have an 8 year old Labrador. How is your puppy doing? My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. It is better but not gone. Was hospitalized for 2 1/2 days. And a bit more stumbling. This is because it doesn't kill adult heartworms. We are now at about 45 days since last simparica and he is back to his old self. Our 9 month 5lb Morkie was prescribed this garbage and we noticed the shakes, his lower lip quivering, and he looks around as if an invisible fly is flying around his head. I have my 14 week old pup simparica (vet recommended) 2 days ago. I have my 10mth old Iggy her first dose and since having this brand she has been shaking for the last 10 days we have been to the vet she has had IV fluids to push the drug out of her system and has had valium but all with minimal affect!!! If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. My vet recommended Simparica Trio for both my dogs (13 year old healthy Collie mix 7 lb chihuahua mix). Although vet wanted to treat him for Addison's I decided to wait it out and fortunately it worked out. Simparica Trio does cover more but after reading both I've decided to use Revolution. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Seizure meds arent working. Im going to keep a close watch on him over the next few days. The exact same thing is happening to my dog now. As of today, Sadie's ability to eventually meet the strict certification requirements in that pursuit, remains guarded, although her progress prior to this event had been stellar. Never again are my dogs getting oral medication for fleas & ticks. Started downhill health issues with initial dose. If anyone has discovered what can help please let me know. Since the weather was turning cold, I stopped giving her the Simparica until spring. After second pill, weve notice he has been a bit down for a couple days. Idk what to do. The vet does not feel it is due to Simparica but i think it could be. To report suspected adverse drug events for these products and/or obtain a copy of the Safety Data Sheet (SDS) or for technical assistance, contact the appropriate manufacturers at the following phone numbers: Merck Animal Health (Bravecto): 800-224-5318, Elanco Animal Health (Credelio): 888-545-5973, Boehringer Ingelheim (Nexgard): 888-637-4251, Zoetis (Simparica, Revolution Plus): 888-963-8471, If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see, Pet owners and veterinarians who have additional questions can contact. Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs. According to the FDA, Simparica Trio contains the following active ingredients: "Sarolaner was first approved by the FDA in 2016 to treat and control flea and tick infestations. she has shaking off and on . Dr said either Simparica (best case scenario), GOLPP or brain tumor. In general dogs tolerate very well sarolaner at the therapeutic dose range (2 to 4 mg/kg). Gave my Olde English Bulldog puppies Simparica Trio on 4/7/21 they are almost 4 month now. After about a week, she started to improve. Thanks all for sharing your experiences. I have had German Shepherds for 40 yrs. Read the package insert and it does list tremors and seizures as a side effect. Wonder why PetSmart offers this if there are so many concerns reported. How long did the itchiness last for your schnauzer? On Friday he was incredibly thirsty - he would drink a full bowl of water and then look at me for more. It comes in a pack of six or 12, but veterinarians typically sell individual doses for growing puppies. I looked up side effects for this drug and was horrified to find that the flea med can cause tremors seizures and worse. She had terrible watery diarrhea and is not interested in eating. After reading all these reports I am convinced this is the reason our baby is so sick. They both got similar issues and this was the only thing they both did. Tuesday morning she woke up with horrible diarrhea. My dog has been vomiting with diarrhea plus he has bumps all over his body from one dose of simparica trio. So new pup goes on garlic tabs-as he growing I'm upping the amount because I wanted him to be protected. They did a blood test (this is literally 7 days later) and his ATL liver levels were off the charts at >2000. Only some dogs show this symptom. #JusticeforCassie My thoughts and prayers are with you all as I go through the same thing with my beautiful Cassie girl. He is my first dog, he is 5yrs old now, and this is all new. I fed him a diet of boiled chicken and rice for 3 days and began to introduce his food which is a limited ingredient type. The Trio product by Simparica is a three-in-one medication to control and prevent flea, tick, and heartworm. Something I will never know what happened to herIf I knew this would kill her I would never had used it. Her last dose of Simparica Trio was given to her on October 1, 2021. I went to banfield hospital and they prescribed this medication for my dog and had thrown up non stop since he was given the pill and wouldnt eat anything and he passed away 10 days later (yesterday). After seeing his condition worsen, that night we took him to an after hours urgent care. I used to use revolution but they dont cover ticks as well. My vet is aware of this and prescribed simparica. Poor dog prob thinks HE did something wrong. Sunday I started watching how much water he was drinking feeling bad that I was restricting him, so I made sure to take him out to pee every few hours. He woke up and seemed much brighter. Simparica is approved for dogs and puppies weighing more than 2.8 pounds and over 6 months of age. All they care about is the money and not the animal. Now I have to pay $100's of dollars on meds to check her antibody and possibly put her on meds for life . I just gave Bentlee my Akita Simparica Trio on the 9th.